Supplement Facts
Cert. of Analysis

HOLESHOT Pre-workout (3 flavors)

$34.99

Used as a pre-workout supplement to promote energy, increase focus and maintain endurance. It encourages the mind and body to respond quickly during a workout and allows more nutrition to flow through the body to your muscles. This pre-workout will not cause sleep disturbances when taken close to the end of the day. It also helps promote muscle mass development.*

Earn up to 35 Points.

SKU: ROC605 Categories: ,

Frequently Bought Together

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Price for all:   $99.97
Formula Purposes & Benefits
HOLESHOT PRE-WORKOUT:

Designed to give you the jump on your workouts, cross training and competition on event days. No pump ingredients so you won’t build lactic acid but still boost energy, endurance and performance. Great for workouts later in the day with a perfect dose of caffeine to get you going but not too much so it won’t keep you up at night.

Available in:
Fruit Punch, Grape and Lemonade flavors.

 

Formula Ingredient Deck Benefits Of Each Ingredient
Vitamin B6 pyridoxal 5′-phosphate (PLP)
  • Serves as a cofactor in more than 150 enzymatic reactions associated in blood sugar regulation, immunity, cardiovascular function, neuronal health, metabolic, and digestive health (38, 40).
  • Reduces plasma glucose (blood sugar levels) via by inhibiting the activity of small-intestinal α-glucosidases (enzymes associated with glucose metabolism) (39).
  • Functions as an antioxidant by counteracting the formation of reactive oxygen species (inflammatory markers) and advanced glycation end-products (38,40).
  • May support blood sugar regulation in women with gestational diabetes (40).
  • cofactor for enzymes involved in DNA metabolism (40).
Niacin (Vitamin B3)
  • Major B vitamin that supports cardiovascular health by inhibiting hepatic(liver) triglyceride synthesis, reducing very low-density lipoprotein (VLDL) secretion, and increasing HDL plasma concentrations (9).
  • Reduces conversion of VLDL into LDL proteins and serum lipoprotein concentrations in plasma (blood) (9).
  • Vital for regulation of gene expression, cell cycle progression, and DNA repair, and cell death (9).
  • Supports healthy inflammatory response via antioxidant and anti-apoptotic (prevention of cell death) properties (9).
  • Prevents pathologies(diseases) such as Pellagra and reduces prevalence of nervous anorexia, cancer, and crohn’s disease (10, 11).
  • Supports sensitization of tumors to radiation via apoptosis (cell death) cascade of tumor mass and improves oxygen delivery to malignant tissues (cancer cells) (12).
  • Supports cognitive health by reducing age-related decline of NAD+, increasing quinolinic acid and reducing neuroinflammation (9).
  • Increased niacin associated NAD+ levels have been shown to increase neurotransmission, learning and memory (9).
  • Niacin reduces the prevalence of neurodegenerative pathologies by preventing mitochondrial dysfunction (9).
Caffeine Anhydrous
  • Optimizes energy, cognitive function, and mental alertness (24).
  • Supplementation with caffeine has been shown to acutely enhance exercise performance (24).
L-Citrulline Malate
  • Supports cardiovascular health and exercise performance by increasing the production of l-arginine (34).
  • Increases nitric oxide production, improves exercise performance, and increases blood flow to exercising skeletal muscle (35).
  • Supports strength increases, exercise endurance, and recovery (34,35).
  • May reduce blood pressure by increasing vascular function (34).
Bioperine
  • Increases absorption of amino acids and curcumin.
Folate (Folic Acid)
  •  May support proper cell growth and DNA synthesis (65).
Vitamin B-12 (Methylcobalamin)
  • Metabolically active, methylated form of Vitamin B12 needed for proper DNA synthesis, folate cycle function, energy production, cognitive function, and immune health (51,53).
  • Aids as an antioxidant via direct scavenging of reactive oxygen species (inflammation), preserving l-glutathione levels (master antioxidant), and reducing oxidative stress (51).
  • May prevent vitamin b-12 deficiency diseases such as anemia, neurodegenerative disease, cardiovascular disease, and osteoporosis (53).
Creatine Monohydrate
  • Optimizes exercise performance, muscle mass, strength, thermoregulation, recovery, and intramuscular stores of phosphocreatine (PCr) (47).
  • Vital for the energy reaction of every cell in the human body as a spatial energy shuttle and energy sensor (47,50).
  • Vital in bioenergetics (metabolic activity) of the brain (50).
  • Fuels CD8 and CD4 T- cell-mediated immunity (immune cells) in cancer tissue (48,49).
  • Supports cognition and focus via replenishment of cerebral storage of creatine (creatine in the brain) (50).
  • Supports cognitive health in brain creatine deficiency associated with neurodegenerative diseases (50).
  • Supports cognitive health by enhancing the facilitation of synaptic glutamate and neurotransmitter uptake (50).
N-Acetyl Tyrosine
  • Supports memory, cognitive flexibility, the executive function of the brain, and convergent thinking (60).
  • The precursor to dopamine and is vital for dopamine synthesis in the brain (60).
  • Supports cognitive function in individuals with high amounts of stress and anxiety (60,61).
  • Increases dopamine levels in highly stressed individuals (60).
Choline Bitrate
  • Essential for cell membrane integrity, cell messaging, fat metabolism, DNA synthesis, immune support, and nervous system function (62,63).
  • Serves as a methyl donor and as a precursor for the production of cell membranes (62).
  • Precursor for acetylcholine (neurotransmitter) which activates receptors in the central nervous system-mediated immune responses (α7nAchR) (64).
  • Lifelong choline supplementation may combat neurodegenerative diseases by reducing amyloid-β plaque load (plaques of degrading neurons) (62).
  • Reduces the concentration of total homocysteine (inflammation marker) in individuals with low levels of folate and other B vitamins (B₂, B₆, and B₁₂) (62).
DMAE Bitrate
  • Increases acetylcholine levels in the brain.
L-Theanine
  • A unique non-protein amino acid found in green tea (Camellia sinensis) (53).
  • Supports mood, mental clarity, and cognitive health, memory, and is a natural anti-depressant/neuroprotective agent (53).
  • Aids as an antidepressant due to partial antagonism for the N-methyl-D-aspartate receptor manifesting its cognitive optimizing effects (53).
  • Reduces the neuropsychiatric side effects of chronic adolescent THC exposure (54).
Bacopa Monnieri
  • Supports cognitive function, memory, alertness, and aids as an anti-stress agent (57).
  • May combat inflammatory conditions such as asthma, bronchitis, dropsy, and rheumatism (56,59).
  • Bacopa has been shown to have anti-inflammatory effects on macrophages (immune cells) and inhibits the release of IL-6 and TNF-α (inflammatory markers) from monocytes (immune cells) (58,59,).
  • A promising candidate for the development of novel therapeutics that target neuroinflammation and have the potential for treating a wide range of CNS disorders including Alzheimer’s disease, depression, and schizophrenia (59).
Proper Use of This Supplement
Suggested Use: Stir 1 rounded scoop with 6-8ounces of cold water and consume 30-45 minutes before beginning activity.

 

Our Formula                                                         Vs                                       Other Formulas on the Market.
1. Uses third-party independently tested ingredients that are made in the USA, GMP certified, and made in an FDA registered facility. 1. Source cheap ingredients from heavily polluted soils. Even “organic” supplements not third-party tested have been removed by FDA due to high levels of heavy metals.
2. Utilizes efficacious evidence-based dosages with optimal ratios of amino acids, nootropics, and pump enhancers to support exercise performance and recovery. 2. Use low amounts of cheap forms of amino acids, nootropics, and pump enhancers that result in poor absorption and muscle growth, recovery, and exercise performance.

Sources:

  1. Guest, N. S., VanDusseldorp, T. A., Nelson, M. T., Grgic, J., Schoenfeld, B. J., Jenkins, N., Arent, S. M., Antonio, J., Stout, J. R., Trexler, E. T., Smith-Ryan, A. E., Goldstein, E. R., Kalman, D. S., & Campbell, B. I. (2021). International society of sports nutrition position stand: caffeine and exercise performance. Journal of the International Society of Sports Nutrition, 18(1), 1. https://doi.org/10.1186/s12970-020-00383-4
  2. Barkhidarian, B., Khorshidi, M., Shab-Bidar, S., & Hashemi, B. (2019). Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis. Avicenna journal of phytomedicine, 9(1), 10–20.
  3. Figueroa, A., Wong, A., Jaime, S. J., & Gonzales, J. U. (2017). Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Current opinion in clinical nutrition and metabolic care, 20(1), 92–98. https://doi.org/10.1097/MCO.0000000000000340
  4. Bahri, S., Zerrouk, N., Aussel, C., Moinard, C., Crenn, P., Curis, E., Chaumeil, J. C., Cynober, L., & Sfar, S. (2013). Citrulline: from metabolism to therapeutic use. Nutrition (Burbank, Los Angeles County, Calif.), 29(3), 479–484. https://doi.org/10.1016/j.nut.2012.07.002
  5. Kreider, R. B., Kalman, D. S., Antonio, J., Ziegenfuss, T. N., Wildman, R., Collins, R., … Lopez, H. L. (2017). International Society of Sports Nutrition position stand: safety and efficacy of creatine supplementation in exercise, sport, and medicine. Journal of the International Society of Sports Nutrition, 14, 18. doi:10.1186/s12970-017-0173-z
  6. Di Biase, S., Ma, X., Wang, X., Yu, J., Wang, Y. C., Smith, D. J., Zhou, Y., Li, Z., Kim, Y. J., Clarke, N., To, A., & Yang, L. (2019). Creatine uptake regulates CD8 T cell antitumor immunity. The Journal of experimental medicine, 216(12), 2869–2882. https://doi.org/10.1084/jem.20182044
  7. Kazak, L., & Cohen, P. (2020). Creatine metabolism: energy homeostasis, immunity and cancer biology. Nature reviews. Endocrinology, 16(8), 421–436. https://doi.org/10.1038/s41574-020-0365-5
  8. Ebrahimi, K., Jourkesh, M., Sadigh-Eteghad, S., Stannard, S. R., Earnest, C. P., Ramsbottom, R., Antonio, J., & Navin, K. H. (2020). Effects of Physical Activity on Brain Energy Biomarkers in Alzheimer’s Diseases. Diseases (Basel, Switzerland), 8(2), 18. https://doi.org/10.3390/diseases8020018
  9. van de Lagemaat, E. E., de Groot, L., & van den Heuvel, E. (2019). Vitamin B12in Relation to Oxidative Stress: A Systematic Review. Nutrients, 11(2), 482. https://doi.org/10.3390/nu11020482
  10. Romain, M., Sviri, S., Linton, D. M., Stav, I., & van Heerden, P. V. (2016). The role of Vitamin B12 in the critically ill–a review. Anaesthesia and intensive care, 44(4), 447–452. https://doi.org/10.1177/0310057X1604400410
  11. Shipton, M. J., & Thachil, J. (2015). Vitamin B12 deficiency – A 21st century perspective. Clinical medicine (London, England), 15(2), 145–150. https://doi.org/10.7861/clinmedicine.15-2-145
  12. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
  13. De Felice, M., Renard, J., Hudson, R., Szkudlarek, H. J., Pereira, B. J., Schmid, S., Rushlow, W. J., & Laviolette, S. R. (2021). l-Theanine Prevents Long-Term Affective and Cognitive Side Effects of Adolescent Δ-9-Tetrahydrocannabinol Exposure and Blocks Associated Molecular and Neuronal Abnormalities in the Mesocorticolimbic Circuitry. The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(4), 739–750. https://doi.org/10.1523/JNEUROSCI.1050-20.2020
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  16. Sukumaran, N. P., Amalraj, A., & Gopi, S. (2019). Neuropharmacological and cognitive effects of Bacopa monnieri (L.) Wettst – A review on its mechanistic aspects. Complementary therapies in medicine, 44, 68–82. https://doi.org/10.1016/j.ctim.2019.03.016
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  19. Velazquez, R., Ferreira, E., Knowles, S., Fux, C., Rodin, A., Winslow, W., & Oddo, S. (2019). Lifelong choline supplementation ameliorates Alzheimer’s disease pathology and associated cognitive deficits by attenuating microglia activation. Aging cell, 18(6), e13037. https://doi.org/10.1111/acel.13037
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  21. Jacobson, S. W., Carter, R. C., Molteno, C. D., Stanton, M. E., Herbert, J. S., Lindinger, N. M., Lewis, C. E., Dodge, N. C., Hoyme, H. E., Zeisel, S. H., Meintjes, E. M., Duggan, C. P., & Jacobson, J. L. (2018). Efficacy of Maternal Choline Supplementation During Pregnancy in Mitigating Adverse Effects of Prenatal Alcohol Exposure on Growth and Cognitive Function: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Alcoholism, clinical and experimental research, 42(7), 1327–1341. https://doi.org/10.1111/acer.13769
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Flavors: Fruit Punch;
Serving Size: 12.5 Grams;
Servings Per Container: 44;
Bottle Color: Black;
Bottle Size: 64 oz;
Lid Color: Black

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* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Weight 30 oz
Dimensions 4.5 × 3.75 × 3.75 in
FLAVOR

FRUIT PUNCH, GRAPE, LEMONADE

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