Forskolin is a popular supplement and research tool that entered medical practice from Ayurvedic medicine. It is obtained from the dried root of an Indian plant known as Plectranthus barbatus or Coleus forskohlii . Used for Weight Loss Forskolin may help treat obesity, according to a small study published in Obesity Research.4 For this investigation, 30 overweight or obese men were assigned either a forskolin supplement (250 milligrams of 10% forskolin extract twice daily) or a placebo. Forskolin works in a similar way too many asthma drugs by boosting the level of a compound known as cyclic adenosine monophosphate (cyclic AMP). Doing so relaxes the air passages and reduces the risk of respiratory spasms.